The Department operates in the following ENEA Reserch Centres and Offices all over Italy: Casaccia, Saluggia, Ispra, Bologna, Faenza, Brasimone, Pisa, Santa Teresa, Rome, Frascati, Trisaia, Brindisi, Palermo, Lampedusa Island.
 

The ENEA Headquarter is located in Rome.

The ENEA Liaison Office in Brussels works to promote and strengthen the ENEA image and participation to the EU, besides providing information, operational consulting and logistical support to ENEA Departments.