Pulsed electric fields: a multi-level view from molecular interactions to medical treatments
This workshop aims to introduce the URSI GASS attendees to the potentialities of the use of ultra-short pulsed electric fields with high amplitude for the manipulation of cells and tissues to promote promising biomedical applications. These signals are proved to be biologically effective and their application needs to be supported at research and industrial level. Description of electric pulse interaction at the molecular level will be proposed during the workshop as well as numerical methods to quantify the induced transmembrane potential following the application of exogenous electric field on single cells (microdosimetry) or cell aggregates (mesodosimetry). Biological results demonstrating the role of PEFs in in vitro and in vivo models will be also offered. These outcomes are key aspects for an aware exploitation of pulse technology in medical treatments whose examples will be provided in the field of neuronal stimulation, immune responses, and cancer therapy.